Hormone replacement therapy and hypercoagulability. Results from the Prospective Danish Climacteric Study

نویسندگان

  • J. J. Sidelmann
  • J. Jespersen
  • L. F. Andersen
  • S. O. Skouby
چکیده

Population One hundred and forty-nine postmenopausal women without previous venous thromboembolic disease. Methods Prothrombin fragment 1þ2 (F1þ2), fibrin degradation products, antithrombin, protein C, total protein S and activated protein C-normalised ratio were measured at baseline and after 6 and 12 months of HRT in six groups of healthy postmenopausal women: (A) no HRT (reference group), (B) continuous oestradiol valerate (E2V) plus cyproterone acetate, (C) cyclic E2V plus cyproterone acetate, (D) continuous combined oestrogen (E2) plus norethindrone acetate, (E) E2 combined with local delivery of levonorgestrel and (F) E2V plus medroxyprogesterone.

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تاریخ انتشار 2003